BNT162B2 (BionTech Code Number: BNT162, PFIZER Code Number: PF-07302048) is a heavy acute call
Susing syndrome coronavirus
2 (SARS-COV-2) spike glycoprotein (S protein) total length
MRNA (MODRNA) and for infectious diseases with SARS-COV-2
Code modified nucleoside
Development has been developed as the essence of mRNA vaccines.In formulation of BNT162B2, two ALC-0315 (amino lipid) and ALC-0159 (PEG lipid) and two structural lipids By mixing with DSPC (1,2-Distearoyl-Sn-Glycero-3-Phosphocholine) and cholesterol Functional lipid as Lipid nanoparticles (LNP) which encapsulate BNT162B2 are formed (hereinafter, “BNT162B2 encapsulated LNP”). ALC-0315 contained in LNP and ALC-0315 and In vivo and in vitro tests and BNT162B2 to evaluate ALC-0159 absorption (PK), metabolism and excretion In-vivo distribution test using luciferase or radiolabeled lipid as an alternative reporter conducted.